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Image Search Results
Journal: Addiction Biology
Article Title: Social threat exposure in juvenile mice promotes cocaine‐seeking by altering blood clotting and brain vasculature
doi: 10.1111/adb.12373
Figure Lengend Snippet: Increased blood coagulation and impairments in brain microvasculature in S‐S cocaine‐abstinent mice. (a) Decreased prothrombin time (PT) and (b) increased vWF mRNA expression were observed in cocaine‐abstinent S‐S mice (PT, N : NS‐S = 3, S‐S = 4; vWF, N: NS‐S = 6, S‐S = 5). (c) Representative images of NeuN immunostaining (left column) and blood vessels stained with L. esculentum (tomato) lectin of the dorsal striatum (STR; top), dentate gyrus (DG; middle) and nucleus accumbens (NAC; bottom) of S‐S and NS‐S mice ( N : NS‐S = 4, S‐S = 4) during withdrawal. (d) Quantitative analysis of blood vessels showing that S‐S mice had fewer capillary branch points and (e) lower signal intensity in the STR, DG and NAC. (f) Cumulative plots of distribution of capillary diameters in the STR and (g) NAC in NS‐S (filled circle) and S‐S (open circle) mice revealing smaller diameter vessels in S‐S compared with NS‐S mice. P < 0.001; *** P < 0.001; ** P < 0.01; * P < 0.05
Article Snippet: For lectin staining (Thurston et al. ) brain sections containing NAc, striatum or hippocampus (dentate gyrus) were first incubated overnight at 4°C in PBS containing 0.3 percent Triton X‐100 with
Techniques: Coagulation, Expressing, Immunostaining, Staining
Journal: PLoS ONE
Article Title: CNS-Targeted Production of IL-17A Induces Glial Activation, Microvascular Pathology and Enhances the Neuroinflammatory Response to Systemic Endotoxemia
doi: 10.1371/journal.pone.0057307
Figure Lengend Snippet: Antibodies/Lectin used for histology.
Article Snippet: Biotin-conjugated tomato lectin,
Techniques: